Ammonia → 4-Amino-5-cyano-6-ethoxy-pyridine-2-carboxylic acid amide

HRID 1364577Notes

Reaction equation

HRID 1364577 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[C:9]([NH2:11])[C:8]([C:12]#[N:13])=[C:7]([O:14][CH2:15][CH3:16])[N:6]=1)=O.[NH3:17]>CO>[NH2:11][C:9]1[C:8]([C:12]#[N:13])=[C:7]([O:14][CH2:15][CH3:16])[N:6]=[C:5]([C:3]([NH2:17])=[O:2])[CH:10]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 40151899Methyl 4-amino-5-cyano-6-ethoxypicolinate

Product 1

HCID 669207154-Amino-5-cyano-6-ethoxy-pyridine-2-carboxylic acid amide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 231 mg (1.00 mmol) of 4-amino-5-cyano-6-ethoxy-pyridine-2-carboxylic acid methyl ester from Example 104A was added 5 mL of 7 M NH3 in methanol. The reaction was stirred at ambient temperature for 5 h, and concentrated in vacuo to 214 mg (100%) of the titled compound as a solid.

Workup

  1. concentrationconcentrated in vacuo to 214 mg (100%) of the titled compound as a solid

Sources & evidence

ORD record
ord-461a762049eb49889c387f91dd14340a
Source dataset
uspto-grants-2011_02
Patent number
US07888374B2

Reaction notes

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