4-(Chlorosulfonyl)benzoic acid → HCID 58614732, compound

HRID 1364814Notes

Reaction equation

HRID 1364814 reaction equation
ClS(C1C=CC(C(O)=O)=CC=1)(=O)=O.CC1OC(C)CNC1.[Cl:22][C:23]1[CH:29]=[CH:28][C:26]([NH2:27])=[CH:25][C:24]=1[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=1.[CH3:36][CH:37]1[CH2:42][N:41]([S:43]([C:46]2[CH:54]=[CH:53][C:49]([C:50](O)=[O:51])=[CH:48][CH:47]=2)(=[O:45])=[O:44])[CH2:40][CH:39]([CH3:55])[O:38]1>>[Cl:22][C:23]1[CH:29]=[CH:28][C:26]([NH:27][C:50](=[O:51])[C:49]2[CH:53]=[CH:54][C:46]([S:43]([N:41]3[CH2:40][CH:39]([CH3:55])[O:38][CH:37]([CH3:36])[CH2:42]3)(=[O:45])=[O:44])=[CH:47][CH:48]=2)=[CH:25][C:24]=1[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=1

Participants

5

Reactant 4

HCID 823854-(Chlorosulfonyl)benzoic acidHCID 1108622,6-DimethylmorpholineHCID 2770973328038-27-3HCID 401519254-Chloro-3-(pyridin-2-yl)aniline

Product 1

HCID 58614732HCID 58614732, compound

Procedure

1 g of 4-(chlorosulfonyl)benzoic acid was reacted with 616 μL of 2,6-dimethylmorpholine via Procedure H. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 120 mg of 4-(2,6-dimethylmorpholinosulfonyl)benzoic acid via Procedure G and purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(2,6-dimethylmorpholinosulfonyl)benzamide. MS (Q1) 486.3 (M)+.

Workup

  1. custompurified by reverse phase HPLC

Sources & evidence

ORD record
ord-035e615de2854dfe9159bf8973453e36
Source dataset
uspto-grants-2011_02
Patent number
US07888364B2

Reaction notes

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