1-Ethylpiperazine → HCID 58614750, compound

HRID 1364816Notes

Reaction equation

HRID 1364816 reaction equation
ClS(C1C=CC(C(O)=O)=CC=1)(=O)=O.C(N1CCNCC1)C.[Cl:22][C:23]1[CH:29]=[CH:28][C:26]([NH2:27])=[CH:25][C:24]=1[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=1.[CH2:36]([N:38]1[CH2:43][CH2:42][N:41]([S:44]([C:47]2[CH:55]=[CH:54][C:50]([C:51](O)=[O:52])=[CH:49][CH:48]=2)(=[O:46])=[O:45])[CH2:40][CH2:39]1)[CH3:37]>>[Cl:22][C:23]1[CH:29]=[CH:28][C:26]([NH:27][C:51](=[O:52])[C:50]2[CH:54]=[CH:55][C:47]([S:44]([N:41]3[CH2:40][CH2:39][N:38]([CH2:36][CH3:37])[CH2:43][CH2:42]3)(=[O:46])=[O:45])=[CH:48][CH:49]=2)=[CH:25][C:24]=1[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=1

Participants

5

Reactant 4

HCID 791961-EthylpiperazineHCID 823854-(Chlorosulfonyl)benzoic acidHCID 861492HCID 861492, compoundHCID 401519254-Chloro-3-(pyridin-2-yl)aniline

Product 1

HCID 58614750HCID 58614750, compound

Procedure

1 g of 4-(chlorosulfonyl)benzoic acid was reacted with 570 mg of 1-ethylpiperazine via Procedure H. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 4-(4-ethylpiperazin-1-ylsulfonyl)benzoic acid via Procedure G and purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(4-ethylpiperazin-1-ylsulfonyl). MS (Q1) 485 (M)+.

Workup

  1. custompurified by reverse phase HPLC
  2. customto yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(4-ethylpiperazin-1-ylsulfonyl)

Sources & evidence

ORD record
ord-b15954113f5f4c548ef3f01579c1979b
Source dataset
uspto-grants-2011_02
Patent number
US07888364B2

Reaction notes

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