Dichloromethane → HCID 66970990, compound

HRID 1365028Notes

Reaction equation

HRID 1365028 reaction equation
C([O:8][C:9]1[C:13]([CH:14]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=2)O)=[C:12]([C:24]2[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=2)[N:11]([CH:32]([CH3:34])[CH3:33])[N:10]=1)C1C=CC=CC=1.ClCCl>C(O)C.[C].[Pd]>[CH:32]([N:11]1[C:12]([C:24]2[CH:25]=[CH:26][C:27]([O:30][CH3:31])=[CH:28][CH:29]=2)=[C:13]([CH2:14][C:16]2[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=2)[C:9](=[O:8])[NH:10]1)([CH3:33])[CH3:34]

Participants

5

Reactant 2

HCID 6344DichloromethaneHCID 66971319HCID 66971319, compound

Product 1

HCID 66970990HCID 66970990, compoundYield 89.9%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To a solution of [3-benzyloxy-1-isopropyl-5-(4-methoxyphenyl)-1H-pyrazol-4-yl]4-methoxy-phenyl methanol (0.11 g) in ethanol (4 mL) was added a catalytic amount of 10% palladium-carbon powder and the mixture was stirred at room temperature under a hydrogen atmosphere overnight. Dichloromethane was added to the mixture and the insoluble material was removed by filtration. The solvent of filtrate was removed under reduced pressure to give the title compound (0.076 g).

Workup

  1. customthe insoluble material was removed by filtration
  2. customThe solvent of filtrate was removed under reduced pressure

Sources & evidence

ORD record
ord-b0dfce2a15b74df9b5943e3f50fe9144
Source dataset
uspto-grants-2011_02
Patent number
US07888487B2

Reaction notes

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