Hydrochloric Acid → 1-(4-((2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-(dimethylamino)ethanone

HRID 1365136Notes

Reaction equation

HRID 1365136 reaction equation
Cl.[O:2]1[CH2:7][CH2:6][N:5]([C:8]2[C:9]3[S:23][C:22]([CH2:24][N:25]4[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]4)=[CH:21][C:10]=3[N:11]=[C:12]([C:14]3[CH:15]=[N:16][C:17]([NH2:20])=[N:18][CH:19]=3)[N:13]=2)[CH2:4][CH2:3]1.[CH3:31][N:32]([CH3:37])[CH2:33][C:34](O)=[O:35]>>[NH2:20][C:17]1[N:18]=[CH:19][C:14]([C:12]2[N:13]=[C:8]([N:5]3[CH2:4][CH2:3][O:2][CH2:7][CH2:6]3)[C:9]3[S:23][C:22]([CH2:24][N:25]4[CH2:26][CH2:27][N:28]([C:34](=[O:35])[CH2:33][N:32]([CH3:37])[CH3:31])[CH2:29][CH2:30]4)=[CH:21][C:10]=3[N:11]=2)=[CH:15][N:16]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 673N,N-DimethylglycineHCID 58234035HCID 58234035, compound

Product 1

HCID 582338851-(4-((2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-(dimethylamino)ethanone

Procedure

The HCl salt of 5-(4-morpholino-6-((piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine (100 mg) was reacted with N,N-dimethylglycine via General Procedure B to generate 38.3 mg of 105. MS (Q1) 498.3 (M)+.

Sources & evidence

ORD record
ord-696b5273379c43498b2ed0f9d6dd029c
Source dataset
uspto-grants-2011_02
Patent number
US07888352B2

Reaction notes

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