1-Methylpiperazine → HCID 24947792, compound

HRID 1365178Notes

Reaction equation

HRID 1365178 reaction equation
Cl[C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH:11]=O)=[CH:8][C:6]=2[N:7]=1.[CH3:19][N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1.[N:26]1[CH:31]=[CH:30][CH:29]=[C:28](B(O)O)[CH:27]=1>>[CH3:19][N:20]1[CH2:25][CH2:24][N:23]([CH2:11][C:9]2[S:10][C:5]3[C:4]([N:13]4[CH2:18][CH2:17][O:16][CH2:15][CH2:14]4)=[N:3][C:2]([C:28]4[CH:27]=[N:26][CH:31]=[CH:30][CH:29]=4)=[N:7][C:6]=3[CH:8]=2)[CH2:22][CH2:21]1

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 27343783-Pyridinylboronic acidHCID 457899852-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

Product 1

HCID 24947792HCID 24947792, compound

Procedure

2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde 10 from Example 3 (100 mg) was reacted with N-methylpiperazine following the protocol in General Procedure C. One half of the crude material was then used with pyridine-3-boronic acid in General Procedure A to give 139 following reversed phase HPLC purification. MS (Q1) 411 (M)+.

Sources & evidence

ORD record
ord-60b5b0d65b2c42eb96c437915ab07ae5
Source dataset
uspto-grants-2011_02
Patent number
US07888352B2

Reaction notes

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