1-Methylpiperazine → HCID 56833947, compound

HRID 1365198Notes

Reaction equation

HRID 1365198 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[Cl:8][C:9]1[N:10]=[C:11]([N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)[C:12]2[CH:17]=[C:16]([CH:18]=O)[S:15][C:13]=2[N:14]=1>>[Cl:8][C:9]1[N:10]=[C:11]([N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)[C:12]2[CH:17]=[C:16]([CH2:18][N:5]3[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]3)[S:15][C:13]=2[N:14]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 568338442-Chloro-4-morpholinothieno[2,3-d]pyrimidine-6-carbaldehyde

Product 1

HCID 56833947HCID 56833947, compound

Procedure

N-Methylpiperazine was reacted with 2-chloro-4-morpholinothieno[2,3-d]pyrimidine-6-carbaldehyde via General Procedure B-3. Purification on silica yielded 2-chloro-6-(4-methyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[2,3-d]pyrimidine.

Workup

  1. customPurification on silica

Sources & evidence

ORD record
ord-016261e71a1649e1bceb5dd420d31abc
Source dataset
uspto-grants-2011_02
Patent number
US07888352B2

Reaction notes

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