Hydrochloric Acid → 1032757-93-9

HRID 1365298Notes

Reaction equation

HRID 1365298 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[S:18][CH:19]=[CH:20][CH:21]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>CO.ClCCl.C(OCC)C>[ClH:22].[S:18]1[CH:19]=[CH:20][CH:21]=[C:17]1[S:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)(=[O:16])=[O:15]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 17255579tert-Butyl 4-(thiophene-2-sulfonyl)piperazine-1-carboxylate

Product 1

HCID 467434531032757-93-9

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

4-(2-Thiophenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (759 mg) was dissolved in methanol (10 ml) and dichloromethane (5 ml), 2M HCl in diethyl ether (11.4 ml) was added and the reaction mixture was stirred at room temperature overnight, then cooled in ice bath, the resulted precipitate was filtered, washed with ether to yield 4-(2-thiophenesulfonyl)-piperazine hydrochloride salt (529 mg).

Workup

  1. temperaturecooled in ice bath
  2. filtrationthe resulted precipitate was filtered
  3. washwashed with ether

Sources & evidence

ORD record
ord-0f5b5cb61e444198a680bf121b6c672d
Source dataset
uspto-grants-2011_02
Patent number
US07888352B2

Reaction notes

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