Hydrochloric Acid → HCID 43810645, compound

HRID 1365305Notes

Reaction equation

HRID 1365305 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO.ClCCl.C(OCC)C>[ClH:24].[F:23][C:19]1[CH:18]=[C:17]([S:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)(=[O:15])=[O:16])[CH:22]=[CH:21][CH:20]=1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 46180234HCID 46180234, compound

Product 1

HCID 43810645HCID 43810645, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

4-(3-Fluoro-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (919 mg) was dissolved in methanol (10 ml) and dichloromethane (5 ml), 2M HCl in diethyl ether (12 ml) was added and the reaction mixture was stirred at room temperature overnight. Volatiles were removed in vacuo to yield 4-(3-fluoro-benzenesulfonyl)-piperazine hydrochloride salt (807 mg).

Workup

  1. customVolatiles were removed in vacuo

Sources & evidence

ORD record
ord-37da83938dfe4c4c89fbe7ae7e64e07c
Source dataset
uspto-grants-2011_02
Patent number
US07888352B2

Reaction notes

Loading…