Hydrochloric Acid → 1-(4-Fluorobenzene-1-sulfonyl)piperazine--hydrogen chloride (1/1)

HRID 1365310Notes

Reaction equation

HRID 1365310 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO.ClCCl.C(OCC)C>[ClH:24].[F:23][C:20]1[CH:19]=[CH:18][C:17]([S:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)(=[O:16])=[O:15])=[CH:22][CH:21]=1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 4634543HCID 4634543, compound

Product 1

HCID 173683141-(4-Fluorobenzene-1-sulfonyl)piperazine--hydrogen chloride (1/1)

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

4-(4-Fluoro-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (937 mg) was dissolved in methanol (10 ml) and dichloromethane (5 ml), 2M HCl in diethyl ether (13.6 ml) was added and the reaction mixture was stirred at room temperature overnight. Volatiles were removed in vacuo to yield 4-(4-fluoro-benzenesulfonyl)-piperazine hydrochloride salt (819 mg).

Workup

  1. customVolatiles were removed in vacuo

Sources & evidence

ORD record
ord-3cb7f9b2fe484308a35840bf7a3e9dbf
Source dataset
uspto-grants-2011_02
Patent number
US07888352B2

Reaction notes

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