2-Methoxyethylamine → HCID 86623553, compound

HRID 1365365Notes

Reaction equation

[CH3:1][O:2][CH2:3][CH2:4][NH2:5].[Cl:6][C:7]1[N:8]=[C:9]([N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)[C:10]2[S:15][C:14]([CH:16]=O)=[CH:13][C:11]=2[N:12]=1>>[Cl:6][C:7]1[N:8]=[C:9]([N:18]2[CH2:19][CH2:20][O:21][CH2:22][CH2:23]2)[C:10]2[S:15][C:14]([CH2:16][NH:5][CH2:4][CH2:3][O:2][CH3:1])=[CH:13][C:11]=2[N:12]=1

Participants

Reactant 2

HCID 80182-Methoxyethylamine

HCID 457899852-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

Product 1

HCID 86623553HCID 86623553, compound

Procedure

Reaction of 2-methoxyethylamine with 2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde 10 using standard reductive amination conditions yielded (2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-(2-methoxy-ethyl)-amine, which was reacted with 1-isopropyl-4-piperidone using the standard reductive amination conditions to yield (2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-(1-isopropyl-piperidin-4-yl)-(2-methoxyethyl)amine.

Sources & evidence

ORD record: ord-886f20a2da7a47a8b440f8ee643acbbe
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07888352B2

Reaction notes

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