Hydrochloric Acid → 2,2-Difluorocyclohexan-1-amine--hydrogen chloride (1/1)

Participants

Reaction Steps

A solution of benzyl 2,2-difluorocyclohexylcarbamate (38 mg, 0.14 mmol) in 6 N HCl (2 mL) was heated at 100° C. for 2 hr. The cooled reaction mixture was washed with ether (3×1 mL) and the aqueous layer was concentrated to give 2,2-difluorocyclohexanamine hydrochloride as a light brown solid (23 mg, 96% crude).

Provenance & Evidence