Hydrochloric Acid → 2,2-Difluorocyclohexan-1-amine--hydrogen chloride (1/1)
Reaction equation
[F:1][C:2]1([F:19])[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[NH:8]C(=O)OCC1C=CC=CC=1.[ClH:20]>>[ClH:20].[F:1][C:2]1([F:19])[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[NH2:8]Participants
3
Procedure
A solution of benzyl 2,2-difluorocyclohexylcarbamate (38 mg, 0.14 mmol) in 6 N HCl (2 mL) was heated at 100° C. for 2 hr. The cooled reaction mixture was washed with ether (3×1 mL) and the aqueous layer was concentrated to give 2,2-difluorocyclohexanamine hydrochloride as a light brown solid (23 mg, 96% crude).
Workup
- customThe cooled reaction mixture
- washwas washed with ether (3×1 mL)
- concentrationthe aqueous layer was concentrated
Sources & evidence
- ORD record
- ord-35a5f82c80044d2fa12c1fedf4bf36d2
- Source dataset
- uspto-grants-2011_02
- Patent number
- US07888376B2
Reaction notes
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