Aluminium lithium hydride → HCID 58920440, compound

HRID 1365539Notes

Reaction equation

HRID 1365539 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C@@:8]([NH:30][C:31](=[O:44])[NH:32][CH2:33][CH:34]([C:40]([F:43])([F:42])[F:41])[CH2:35][CH2:36][C:37](O)=[O:38])([C:16]2[CH:21]=[C:20]([O:22][C:23]([F:28])([F:27])[CH:24]([F:26])[F:25])[CH:19]=[C:18]([F:29])[CH:17]=2)[CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:6][CH:7]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C@@:8]([NH:30][C:31]([NH:32][CH2:33][CH:34]([C:40]([F:42])([F:43])[F:41])[CH2:35][CH2:36][CH2:37][OH:38])=[O:44])([C:16]2[CH:21]=[C:20]([O:22][C:23]([F:27])([F:28])[CH:24]([F:25])[F:26])[CH:19]=[C:18]([F:29])[CH:17]=2)[CH2:9][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 58920968HCID 58920968, compound

Product 1

HCID 58920440HCID 58920440, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 4-((3-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl)-2-phenylethyl)ureido)methyl)-5,5,5-trifluoropentanoic acid (40 mg, 0.061 mmol), prepared by method described in Procedure 3, 5, 6, 7 and 2, in anhydrous THF (1.5 mL) added was dropwise LAH (1.0 M in THF, 0.2 mL). The reaction mixture was stirred at rt for 40 min, then quenched by the addition of 4 N NaOH (1 mL). The aqueous portion was extracted with EtOAc (3×20 mL). The combined organic portions were washed with water and sat. NaCl, dried over Na2SO4, filtered and concentrated under reduced pressure to yield a yellow oil. The resulting oil was purified by preparative HPLC (YMC ODS S5 30×100 mm column 20-100% MeOH (90% in water, 0.1% TFA) gradient over 10 min with flow rate 40 mL/min and UV detection at 220 nm), then further purified by ISCO chromatography (4 g) with 0-50% EtOAc in hexane over 18 min (RT=14-15.5 min) to yield 1-((S)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl)-2-phenylethyl)-3-(5-hydroxy-2-(trifluoromethyl)pentyl)urea as white solid (30 mg, 77% yield). LCMS: RT=2.003 min [M+H] 639 (LCMS Method 2). HPLC: RT=4.10 min, 100% purity (HPLC Method 1). NMR: 400 MHz 1H (CDCl3) 8.17 ppm, 1H, s; 7.59 ppm, 1H, dd, J=8.57, 2.42 Hz; 7.05 ppm, 7H, m; 6.82 ppm, 1H, d, J=8.79 Hz; 6.51 ppm, 2H, t, J=6.81 Hz; 5.82 ppm, 1H, m; 4.60 ppm, 1H, ddd, J=12.08, 6.37, 6.15 Hz; 4.29 ppm, 1H, d, J=12.74 Hz; 3.56 ppm, 2H, dt, J=10.55, 5.27 Hz; 3.43 ppm, 2H, m; 3.34 ppm, 1H, m; 1.64 ppm, 4H, m; 1.54 ppm, 2H, s.

Workup

  1. additionadded
  2. customquenched by the addition of 4 N NaOH (1 mL)
  3. extractionThe aqueous portion was extracted with EtOAc (3×20 mL)
  4. washThe combined organic portions were washed with water and sat. NaCl
  5. dry with materialdried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure
  8. customto yield a yellow oil
  9. customThe resulting oil was purified by preparative HPLC (YMC ODS S5 30×100 mm column 20-100% MeOH (90% in water, 0.1% TFA) gradient over 10 min with flow rate 40 mL/min and UV detection at 220 nm)
  10. customfurther purified by ISCO chromatography (4 g) with 0-50% EtOAc in hexane over 18 min (RT=14-15.5 min)

Sources & evidence

ORD record
ord-f0e52650d8e14a87a99b3f4af4f46cc8
Source dataset
uspto-grants-2011_02
Patent number
US07888376B2

Reaction notes

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