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HRID1365786

反应详情

EQUATION

反应方程式

HRID 1365786 的结构方程式

REACTANTS

反应物

3
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：CN(C(=O)OC(C)(C)C)c1ccc(B2OC(C)(C)C(C)(C)O2)cn1
HCID44541676

tert-Butyl methyl[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate

C17H27BN2O4

结构：COC(C)(C)c1nc2c(N3CCOCC3)nc(Cl)nc2s1
HCID86630067

未命名化合物

PRODUCTS

生成物

1
结构：CNc1ccc(-c2nc(N3CCOCC3)c3nc(C(C)(C)OC)sc3n2)cn1
HCID25253836

未命名化合物

PROCEDURE

实验过程

Crude 4-(5-chloro-2-(2-methoxypropan-2-yl)thiazolo[5,4-d]pyrimidin-7-yl)morpholine (60 mg) was reacted with tert-butyl methyl(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate via general procedure A. This crude product was then treated with TFA to remove residual protecting group and purified via reverse phase HPLC to get 58.4 mg 102. MS (Q1) 401.2 (M)+.

WORKUP

后处理

  1. customto remove residual
  2. custompurified via reverse phase HPLC