1,1-Dimethylethyl 2,2-dimethyl-1-piperazinecarboxylate → 4-(5-Chloro-7-morpholin-4-ylthiazolo[4,5-d]pyrimidin-2-ylmethyl)-2,2-dimethylpiperazine-1-carboxylic acid tert-butyl ester

HRID 1365866Notes

Reaction equation

HRID 1365866 reaction equation
C(OC(N1C[CH:14]2[CH:10]([CH2:11][N:12]([CH2:16][C:17]3[S:18][C:19]4[C:24]([N:25]5[CH2:30][CH2:29][O:28][CH2:27][CH2:26]5)=[N:23][C:22]([Cl:31])=[N:21][C:20]=4[N:32]=3)[CH2:13]2)[CH2:9]1)=O)(C)(C)C.[C:33]([O:37][C:38]([N:40]1CCNC[C:41]1(C)C)=[O:39])([CH3:36])([CH3:35])[CH3:34]>>[C:33]([O:37][C:38]([N:40]1[CH2:41][CH2:13][N:12]([CH2:16][C:17]2[S:18][C:19]3[C:24]([N:25]4[CH2:26][CH2:27][O:28][CH2:29][CH2:30]4)=[N:23][C:22]([Cl:31])=[N:21][C:20]=3[N:32]=2)[CH2:11][C:10]1([CH3:14])[CH3:9])=[O:39])([CH3:36])([CH3:35])[CH3:34]

Participants

3

Reactant 2

HCID 299224001,1-Dimethylethyl 2,2-dimethyl-1-piperazinecarboxylateHCID 582349375-(5-Chloro-7-morpholin-4-yl-thiazolo[4,5-d]pyrimidin-2-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester

Product 1

HCID 582349574-(5-Chloro-7-morpholin-4-ylthiazolo[4,5-d]pyrimidin-2-ylmethyl)-2,2-dimethylpiperazine-1-carboxylic acid tert-butyl ester

Procedure

Prepared according to the method used in the preparation of 5-(5-chloro-7-morpholin-4-ylthiazolo[4, 5-d]-pyrimidin-2-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester using 2,2-dimethylpiperazine-1-carboxylic acid tert-butyl ester in place of hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester. The title compound was obtained as a yellow solid (100 mg, 38%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-b7537ac87a2448f292dc675d36eeb3a1
Source dataset
uspto-grants-2011_02
Patent number
US07893060B2

Reaction notes

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