1-(Cyclopropylmethyl)piperazine → 5-Chloro-2-(4-cyclopropylmethylpiperazin-1-ylmethyl)-7-morpholin-4-ylthiazolo[4,5-d]pyrimidine

HRID 1365872Notes

Reaction equation

HRID 1365872 reaction equation
C(OC(N1CC2C([CH2:11][N:12]([CH2:16][C:17]3[S:18][C:19]4[C:24]([N:25]5[CH2:30][CH2:29][O:28][CH2:27][CH2:26]5)=[N:23][C:22]([Cl:31])=[N:21][C:20]=4[N:32]=3)[CH2:13]2)C1)=O)(C)(C)C.[CH:33]1([CH2:36][N:37]2[CH2:42]CNC[CH2:38]2)[CH2:35][CH2:34]1>>[Cl:31][C:22]1[N:23]=[C:24]([N:25]2[CH2:30][CH2:29][O:28][CH2:27][CH2:26]2)[C:19]2[S:18][C:17]([CH2:16][N:12]3[CH2:11][CH2:42][N:37]([CH2:36][CH:33]4[CH2:35][CH2:34]4)[CH2:38][CH2:13]3)=[N:32][C:20]=2[N:21]=1

Participants

3

Reactant 2

HCID 9658751-(Cyclopropylmethyl)piperazineHCID 582349375-(5-Chloro-7-morpholin-4-yl-thiazolo[4,5-d]pyrimidin-2-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester

Product 1

HCID 582349535-Chloro-2-(4-cyclopropylmethylpiperazin-1-ylmethyl)-7-morpholin-4-ylthiazolo[4,5-d]pyrimidine

Procedure

Prepared according to the method used in the preparation of 5-(5-chloro-7-morpholin-4-ylthiazolo[4,5-d]pyrimidin-2-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester using 1-cyclopropylmethylpiperazine in place of hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester. The title compound was obtained as a yellow solid (170 mg, 58%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-270e80c365c049088da8204bd9b3f161
Source dataset
uspto-grants-2011_02
Patent number
US07893060B2

Reaction notes

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