HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Cyclopropylmethyl)piperazine → 5-Chloro-2-(4-cyclopropylmethylpiperazin-1-ylmethyl)-7-morpholin-4-ylthiazolo[4,5-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Cyclopropylmethyl)piperazine | HCID 965875 | — |
| Reactant | 5-(5-Chloro-7-morpholin-4-yl-thiazolo[4,5-d]pyrimidin-2-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester | HCID 58234937 | — |
| Product | 5-Chloro-2-(4-cyclopropylmethylpiperazin-1-ylmethyl)-7-morpholin-4-ylthiazolo[4,5-d]pyrimidine | HCID 58234953 | — |
Reaction Steps
Prepared according to the method used in the preparation of 5-(5-chloro-7-morpholin-4-ylthiazolo[4,5-d]pyrimidin-2-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester using 1-cyclopropylmethylpiperazine in place of hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester. The title compound was obtained as a yellow solid (170 mg, 58%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893060B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-270e80c365c049088da8204bd9b3f161 |
| Source note | uspto-grants-2011_02 |