N,N-Dimethylpiperidin-4-amine → [1-(5-Chloro-7-morpholin-4-ylthiazolo[4,5-d]pyrimidin-2-yl-methyl)-piperidin-4-yl]dimethylamine

HRID 1365873Notes

Reaction equation

HRID 1365873 reaction equation
C(O[C:6]([N:8]1[CH2:15][CH:14]2[CH:10]([CH2:11][N:12]([CH2:16][C:17]3[S:18][C:19]4[C:24]([N:25]5[CH2:30][CH2:29][O:28][CH2:27][CH2:26]5)=[N:23][C:22]([Cl:31])=[N:21][C:20]=4[N:32]=3)[CH2:13]2)[CH2:9]1)=O)(C)(C)C.CN(C)C1CCNCC1>>[Cl:31][C:22]1[N:23]=[C:24]([N:25]2[CH2:26][CH2:27][O:28][CH2:29][CH2:30]2)[C:19]2[S:18][C:17]([CH2:16][N:12]3[CH2:13][CH2:14][CH:15]([N:8]([CH3:6])[CH3:9])[CH2:10][CH2:11]3)=[N:32][C:20]=2[N:21]=1

Participants

3

Reactant 2

HCID 417391N,N-Dimethylpiperidin-4-amineHCID 582349375-(5-Chloro-7-morpholin-4-yl-thiazolo[4,5-d]pyrimidin-2-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester

Product 1

HCID 58234959[1-(5-Chloro-7-morpholin-4-ylthiazolo[4,5-d]pyrimidin-2-yl-methyl)-piperidin-4-yl]dimethylamine

Procedure

Prepared according to the method used in the preparation of 5-(5-chloro-7-morpholin-4-ylthiazolo[4,5-d]pyrimidin-2-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester using dimethylpiperidin-4-ylamine in place of hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester. The title compound was obtained as an orange solid (244 mg, 40%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-1018fb567d8e401cb90faba835b977a2
Source dataset
uspto-grants-2011_02
Patent number
US07893060B2

Reaction notes

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