HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethylpiperidin-4-amine → [1-(5-Chloro-7-morpholin-4-ylthiazolo[4,5-d]pyrimidin-2-yl-methyl)-piperidin-4-yl]dimethylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethylpiperidin-4-amine | HCID 417391 | — |
| Reactant | 5-(5-Chloro-7-morpholin-4-yl-thiazolo[4,5-d]pyrimidin-2-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester | HCID 58234937 | — |
| Product | [1-(5-Chloro-7-morpholin-4-ylthiazolo[4,5-d]pyrimidin-2-yl-methyl)-piperidin-4-yl]dimethylamine | HCID 58234959 | — |
Reaction Steps
Prepared according to the method used in the preparation of 5-(5-chloro-7-morpholin-4-ylthiazolo[4,5-d]pyrimidin-2-ylmethyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester using dimethylpiperidin-4-ylamine in place of hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester. The title compound was obtained as an orange solid (244 mg, 40%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893060B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-1018fb567d8e401cb90faba835b977a2 |
| Source note | uspto-grants-2011_02 |