N,N-Dimethylpiperidin-4-amine → [1-(5-Chloro-7-morpholin-4-ylthiazolo[5,4-d]pyrimidin-2-ylmethyl)piperidin-4-yl]dimethylamine

HRID 1365878Notes

Reaction equation

HRID 1365878 reaction equation
[N:1]1([CH:5]2[CH2:10][CH2:9][N:8]([CH2:11][C:12]3[S:13][C:14]4[N:15]=[C:16]([Cl:27])[N:17]=[C:18]([N:21]5[CH2:26][CH2:25][O:24][CH2:23][CH2:22]5)[C:19]=4[N:20]=3)[CH2:7][CH2:6]2)[CH2:4]C[CH2:2]1.CN(C)C1CCNCC1>>[Cl:27][C:16]1[N:17]=[C:18]([N:21]2[CH2:22][CH2:23][O:24][CH2:25][CH2:26]2)[C:19]2[N:20]=[C:12]([CH2:11][N:8]3[CH2:7][CH2:6][CH:5]([N:1]([CH3:4])[CH3:2])[CH2:10][CH2:9]3)[S:13][C:14]=2[N:15]=1

Participants

3

Reactant 2

HCID 417391N,N-Dimethylpiperidin-4-amineHCID 582349332-(4-Azetidin-1-ylpiperidin-1-ylmethyl)-5-chloro-7-morpholin-4-ylthiazolo[5,4-d]pyrimidine

Product 1

HCID 58234944[1-(5-Chloro-7-morpholin-4-ylthiazolo[5,4-d]pyrimidin-2-ylmethyl)piperidin-4-yl]dimethylamine

Procedure

Prepared according to the method used in the preparation of 2-(4-azetidin-1-ylpiperidin-1-ylmethyl)-5-chloro-7-morpholin-4-ylthiazolo[5,4-d]pyrimidine using dimethylpiperidin-4-ylamine in place of 4-azetidin-1-ylpiperidine. The title compound was obtained as a pale yellow solid (101 mg, 72%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a5156f47902145519cab7982c40b831b
Source dataset
uspto-grants-2011_02
Patent number
US07893060B2

Reaction notes

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