HRID1365888

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)[C@@H](CCCN)C(=O)N[C@H](CCc1ccccc1)C(=O)OCc1ccccc1

HCID86602420

未命名化合物

HCID178418361

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)[C@@H](CCCN)C(=O)N[C@H](CCc1ccccc1)C(=O)O

HCID86602421

未命名化合物

收率 104.7%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A solution of NaNd-bis-Boc-L-Ornithyl-D-Homophenylalanine Benzyl ester (2.80 g, 4.80 mmol) in methanol (200 mL) was treated with 10% Pd/C catalyst (0:2 g) and stirred in the atmosphere of hydrogen at 25° C. for 3 hr. The catalyst was removed by filtration through Celite pad and the filtrate evaporated to dryness to give the title product (2.48 g).

WORKUP

后处理

customThe catalyst was removed by filtration through Celite pad
customthe filtrate evaporated to dryness

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-46b23d3cd4cf4fd69f32be6c7e94a4ee
来源数据集: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07893020B2
来源说明: uspto-grants-2011_02

反应 SMILES

C([O:8][C:9](=[O:42])[C@@H:10]([CH2:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[NH:11][C:12](=[O:33])[C@H:13]([CH2:29][CH2:30][CH2:31][NH2:32])[N:14]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])C1C=CC=CC=1.[H][H]>CO.[Pd]>[C:15]([N:14]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[C@H:13]([C:12]([NH:11][C@@H:10]([C:9]([OH:42])=[O:8])[CH2:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)=[O:33])[CH2:29][CH2:30][CH2:31][NH2:32])([O:17][C:18]([CH3:20])([CH3:19])[CH3:21])=[O:16]