反应详情

N-(Diphenylmethylene) (3,4,5-trifluoro)-D,L-Phenylalanine ethyl ester (1.33 g, 3.2 mmol) was suspended in water (15 mL) at 25° C. and treated with conc. hydrochloric acid (5 mL). The mixture was heated at reflux for 4 hrs and evaporated to dryness. The residue was triturated with diethyl ether (4×20 mL). The solid was filtered and dried to afford title compound (0.72 g)

1. temperatureThe mixture was heated
2. temperatureat reflux for 4 hrs
3. customevaporated to dryness
4. customThe residue was triturated with diethyl ether (4×20 mL)
5. filtrationThe solid was filtered
6. customdried