Hydrochloric Acid → 2-Amino-3-(3,4,5-trifluorophenyl)propanoic acid hydrochloride

HRID 1365893Notes

Reaction equation

HRID 1365893 reaction equation
C([O:3][C:4](=[O:30])[CH:5]([CH2:20][C:21]1[CH:26]=[C:25]([F:27])[C:24]([F:28])=[C:23]([F:29])[CH:22]=1)[N:6]=C(C1C=CC=CC=1)C1C=CC=CC=1)C.[ClH:31]>O>[ClH:31].[F:27][C:25]1[CH:26]=[C:21]([CH:22]=[C:23]([F:29])[C:24]=1[F:28])[CH2:20][CH:5]([C:4]([OH:30])=[O:3])[NH2:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58584141N-(Diphenylmethylene) (3,4,5-trifluoro)-D,L-Phenylalanine ethyl ester

Product 1

HCID 669639102-Amino-3-(3,4,5-trifluorophenyl)propanoic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

N-(Diphenylmethylene) (3,4,5-trifluoro)-D,L-Phenylalanine ethyl ester (1.33 g, 3.2 mmol) was suspended in water (15 mL) at 25° C. and treated with conc. hydrochloric acid (5 mL). The mixture was heated at reflux for 4 hrs and evaporated to dryness. The residue was triturated with diethyl ether (4×20 mL). The solid was filtered and dried to afford title compound (0.72 g)

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 4 hrs
  3. customevaporated to dryness
  4. customThe residue was triturated with diethyl ether (4×20 mL)
  5. filtrationThe solid was filtered
  6. customdried

Sources & evidence

ORD record
ord-9906403db9994456951b6cf66395f98b
Source dataset
uspto-grants-2011_02
Patent number
US07893020B2

Reaction notes

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