HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 44138497, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-Pyrimidinecarboxaldehyde, 4-amino-6-chloro- | HCID 84230 | — |
| Reactant | 1-(3-Fluorobenzyl)-1H-indazol-5-amine | HCID 7147073 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 44138497 | HCID 44138497 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
To a mixture of 4-amino-6-chloro-pyrimidine-5-carbaldehyde (95.5 mg, 0.61 mmol) and 1-(3-fluoro-benzyl)-1H-indazol-5-ylamine (147 mg, 0.61 mmol) in DMSO (1.5 mL) was added diisopropylethylamine (DIEA, 79 mg, 0.61 mmol). The mixture was stirred at 100° C. for 2 h, cooled to room temperature, then partitioned between ethyl acetate and H2O. The combined ethyl acetate extracts were dried over Na2SO4 and evaporated to afford a yellow solid, which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893064B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-d4c1453e96244806b7d2699a7e34b52c |
| Source note | uspto-grants-2011_02 |