Pyridine → 1-Piperazinecarbonyl chloride, 4-(methylsulfonyl)-

HRID 1365925Notes

Reaction equation

HRID 1365925 reaction equation
[Cl:1][C:2](Cl)([O:4]C(=O)OC(Cl)(Cl)Cl)Cl.[CH3:13][S:14]([N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)(=[O:16])=[O:15].N1C=CC=CC=1>C(Cl)Cl>[CH3:13][S:14]([N:17]1[CH2:22][CH2:21][N:20]([C:2]([Cl:1])=[O:4])[CH2:19][CH2:18]1)(=[O:16])=[O:15]

Participants

5

Reactant 3

HCID 1049PyridineHCID 94429TriphosgeneHCID 7091611-(Methylsulfonyl)piperazine

Product 1

HCID 798864701-Piperazinecarbonyl chloride, 4-(methylsulfonyl)-Yield 159.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a stirred solution of carbonic acid ditrichloromethyl ester (triphosgene) (1.81 g, 6.09 mmol) in CH2Cl2 (30 ml) at 0° C., was added a solution of 1-methanesulfonyl-piperazine (2.0 g, 12.2 mmol) and pyridine (1.08 ml, 13.4 mmol) in CH2Cl2 (5 ml) over 30 minutes. The temperature was raised to RT, and stirring was continued over night. The organic phase was washed with H2O, dried over Na2SO4. Purification by flash chromatography (SiO2, EtOAc) yielded 2.20 g (79%) of the title compound as white solid.

Workup

  1. waitwas continued over night
  2. washThe organic phase was washed with H2O
  3. dry with materialdried over Na2SO4
  4. customPurification by flash chromatography (SiO2, EtOAc)

Sources & evidence

ORD record
ord-d1e5bebb638444758204fb6e7da5bb21
Source dataset
uspto-grants-2011_02
Patent number
US07893062B2

Reaction notes

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