Oxalyl chloride → 4-Oxocyclohexanecarbonyl chloride

HRID 1365928Notes

Reaction equation

HRID 1365928 reaction equation
[O:1]=[C:2]1[CH2:7][CH2:6][CH:5]([C:8]([OH:10])=O)[CH2:4][CH2:3]1.C(Cl)(=O)C([Cl:14])=O>C(Cl)Cl>[O:1]=[C:2]1[CH2:7][CH2:6][CH:5]([C:8]([Cl:14])=[O:10])[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 1927304-Oxocyclohexanecarboxylic acid

Product 1

HCID 269673534-Oxocyclohexanecarbonyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of 4-oxo-cyclohexanecarboxylic acid (commercially available) (115 mg, 0.81 mmol) in CH2Cl2 (3 ml) was added oxalyl chloride (205 mg, 1.61 mmol). The reaction mixture was stirred at RT over night, and then concentrated under vacuo. The product was used directly in the next step without further purification.

Workup

  1. concentrationconcentrated under vacuo
  2. customThe product was used directly in the next step without further purification

Sources & evidence

ORD record
ord-5a9cf2db2bb4427888adf593b90aa026
Source dataset
uspto-grants-2011_02
Patent number
US07893062B2

Reaction notes

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