反应详情

To a stirred solution of 2-[1-(4-nitro-phenyl)-1H-[1,2,3]triazol-4-yl]-pyridine (0.149 g, 0.556 mmol) in 1:1 THF/EtOH (8 mL) is added tin (II) dichloride dihydrate (0.439 g, 1.95 mmol) and the mixture is stirred at room temperature for 22 hours. The solvent is removed in vacuo and 2N NaOH (3 mL) added to the residue. The mixture is stirred for 1 hour, diluted with water and extracted with DCM (3×40 mL). The organic layers are dried over Na2SO4, filtered and evaporated to give a crude product purified by Isolute FlashSilicaII Cartridge chromatography, eluting with 98:2 DCM:MeOH. The fractions containing the title compound are combined and evaporated to afford the desired compound as a yellow solid (41.4 mg, 31%).

1. customThe solvent is removed in vacuo and 2N NaOH (3 mL)
2. additionadded to the residue
3. stirringThe mixture is stirred for 1 hour
4. additiondiluted with water
5. extractionextracted with DCM (3×40 mL)
6. dry with materialThe organic layers are dried over Na2SO4
7. filtrationfiltered
8. customevaporated
9. customto give a crude product
10. custompurified by Isolute FlashSilicaII Cartridge chromatography
11. washeluting with 98:2 DCM
12. additionThe fractions containing the title compound
13. customevaporated