Dichloromethane → Tert-butyl 4-(acetyloxymethyl)-3-(methoxymethoxy)piperidine-1-carboxylate

HRID 136626Notes

Reaction equation

HRID 136626 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([OH:19])[CH:11]([CH2:14][O:15][C:16]([CH3:17])=[O:18])[CH2:12][CH2:13]1.[CH:20]([N:21]([CH2:22][CH3:23])[CH:24]([CH3:25])[CH3:26])([CH3:27])[CH3:28].[Cl:29][CH2:30][O:31][CH3:32].[Cl:33][CH2:34][Cl:35]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([O:19][CH2:30][O:31][CH3:32])[CH:11]([CH2:14][O:15][C:16]([CH3:17])=[O:18])[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 7864Chloromethyl Methyl EtherHCID 81531DiisopropylethylamineHCID 67387621Tert-butyl 4-(acetyloxymethyl)-3-hydroxypiperidine-1-carboxylate

Product 1

HCID 67387457Tert-butyl 4-(acetyloxymethyl)-3-(methoxymethoxy)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-ae101df62f794ec3841c5fa2f5485176
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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