Sodium Hydroxide → p-Propionylbenzoic acid

HRID 1366295노트

반응식

HRID 1366295 반응식
[CH3:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9]C(C#N)=[CH:7][CH:6]=1)=[O:4].[OH-:13].[Na+].[O:15]1[CH2:20][CH2:19]OCC1>O>[C:3]([C:5]1[CH:10]=[CH:9][C:19]([C:20]([OH:15])=[O:13])=[CH:7][CH:6]=1)(=[O:4])[CH2:2][CH3:1]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 312751,4-DioxaneHCID 107732464-Propanoylbenzonitrile

생성물 1

HCID 20202p-Propionylbenzoic acid수율 98%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

4-Cyanopropiophenone (4.67 g, 29.3 mmol) was refluxed with 2N NaOH (90 mL, 180 mmol) and dioxane (90 mL) at 95° C. overnight. The mixture was diluted with water (150 mL), washed with ether (75 mL), acidified to pH 2 with concentrated HCl, and extracted with ether (3×75 mL). The organic phase was washed with saturated aqueous NaCl (3×75 mL), dried, and concentrated to give a yellow solid (5.12 g, 98%).

후처리

  1. washwashed with ether (75 mL)
  2. extractionextracted with ether (3×75 mL)
  3. washThe organic phase was washed with saturated aqueous NaCl (3×75 mL)
  4. customdried
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-8b9455b4dc4147e4bf8e392a38edd3dc
출처 데이터셋
uspto-grants-2011_02
특허 번호
US07893067B2

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