反应详情

To a solution of 4′-hydroxyacetophenone (101 g, 0.74 mole) in acetone (800 mL) was added 1-bromo-2-chloroethane (638 g, 4.45 mole) followed by K2CO3 (307 g, 2.22 mole). The reaction was heated to reflux for 48 h then filtered. The K2CO3 was washed with acetone (1 L) and the filtrate was evaporated. The residue was then partitioned between EtOAc (800 mL) and 1 N NaOH (250 mL). The organic layer was washed with 1 N NaOH (250 mL) then dried and evaporated to yield 146 g of the desired product (99% yield).

1. temperatureThe reaction was heated
2. temperatureto reflux for 48 h
3. filtrationthen filtered
4. washThe K2CO3 was washed with acetone (1 L)
5. customthe filtrate was evaporated
6. customThe residue was then partitioned between EtOAc (800 mL) and 1 N NaOH (250 mL)
7. washThe organic layer was washed with 1 N NaOH (250 mL)
8. customthen dried
9. customevaporated