反应详情

A solution of tris(1,1-dimethylethyl)2-{2-chloro-5-fluoro-6-[(1-methylethyl)amino]-4-pyrimidinyl}-1,1,2-hydrazinetricarboxylate (597 mg, 1.15 mmol) in MeOH (5 mL) and 4.0M HCl in dioxane (5 mL) was stirred at room temperature overnight. After filtering away the precipitate, the solvent was removed in vacuo, providing the crude 2-chloro-5-fluoro-6-hydrazino-N-(1-methylethyl)-4-pyrimidinamine, presumably as the tri-HCl salt. LCMS: (M+H)+: 219.9.

1. filtrationAfter filtering away the precipitate
2. customthe solvent was removed in vacuo