Hydrochloric Acid → (3S)-3-amino-1-methyl-1,3,4,7-tetrahydro-2H-azepin-2-one

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Reaction Steps

To a solution of 1,1-dimethylethyl [(3S)-1-methyl-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl]carbamate (0.6 g, 2.5 mmol) in DCM (4 mL) was added HCl (6.2 mL, 25 mmol, 4M in dioxane) and the resulting mixture was stirred for 12 hours. Removal of the solvents under reduced pressure yielded (3S)-3-amino-1-methyl-1,3,4,7-tetrahydro-2H-azepin-2-one.HCl (500 mg, quantitative). LCMS: (M+H)+: not detected.

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