反应详情

To a solution of 1,1-dimethylethyl [(3S)-1-methyl-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl]carbamate (0.6 g, 2.5 mmol) in DCM (4 mL) was added HCl (6.2 mL, 25 mmol, 4M in dioxane) and the resulting mixture was stirred for 12 hours. Removal of the solvents under reduced pressure yielded (3S)-3-amino-1-methyl-1,3,4,7-tetrahydro-2H-azepin-2-one.HCl (500 mg, quantitative). LCMS: (M+H)+: not detected.

1. customRemoval of the solvents under reduced pressure