Hydrochloric Acid → (2S)-1,2-Dimethylpiperazine--hydrogen chloride (1/2)

Participants

Reaction Steps

1,1-Dimethylethyl (3S)-3,4-dimethyl-1-piperazinecarboxylate (3.15 g, 14.7 mmol) in 1N HCl (40 mL) was stirred overnight. Then 4M HCl in 1,4-dioxane (25 mL) was added and the reaction was left to stir overnight. Removed volatiles in vacuo to provide (2S)-1,2-dimethylpiperazine dihydrochloride as a white solid (2.88 g). LCMS: (M+H)+=115.1.

Provenance & Evidence