Hydrochloric Acid → (2S)-1,2-Dimethylpiperazine--hydrogen chloride (1/2)

HRID 1366446Notes

Reaction equation

HRID 1366446 reaction equation
[CH3:1][C@@H:2]1[N:7]([CH3:8])[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.[ClH:16]>O1CCOCC1>[ClH:16].[ClH:16].[CH3:8][N:7]1[CH2:6][CH2:5][NH:4][CH2:3][C@@H:2]1[CH3:1]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 29920718HCID 29920718, compound

Product 1

HCID 66935895(2S)-1,2-Dimethylpiperazine--hydrogen chloride (1/2)

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1,1-Dimethylethyl (3S)-3,4-dimethyl-1-piperazinecarboxylate (3.15 g, 14.7 mmol) in 1N HCl (40 mL) was stirred overnight. Then 4M HCl in 1,4-dioxane (25 mL) was added and the reaction was left to stir overnight. Removed volatiles in vacuo to provide (2S)-1,2-dimethylpiperazine dihydrochloride as a white solid (2.88 g). LCMS: (M+H)+=115.1.

Workup

  1. waitthe reaction was left

Sources & evidence

ORD record
ord-73f2206e50e84d1c8dacff5ccf99f8fd
Source dataset
uspto-grants-2011_02
Patent number
US07893056B2

Reaction notes

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