HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (2R)-1,2-dimethylpiperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 66936371 | HCID 66936371 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (2R)-1,2-dimethylpiperazine dihydrochloride | HCID 66936088 | — |
Reaction Steps
1,1-Dimethylethyl (3R)-3,4-dimethyl-1-piperazinecarboxylate (2.70 g, 12.6 mmol) in 1N HCl (25 mL) was stirred overnight. Then 4M HCl in 1,4-dioxane (25 mL) was added and the reaction was left to stir overnight. The volatiles were removed in vacuo to provide (2R)-1,2-dimethylpiperazine dihydrochloride as a white solid (2.53 g). LCMS: (M+H)+=115.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893056B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-43b82bfd29924ea68eb931ab4d446c8d |
| Source note | uspto-grants-2011_02 |