Hydrochloric Acid → (R)-1,2-Dimethyl-piperazine dihydrochloride

HRID 1366452Notes

Reaction equation

HRID 1366452 reaction equation
[CH3:1][C@H:2]1[N:7]([CH3:8])[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.[ClH:16]>O1CCOCC1>[ClH:16].[ClH:16].[CH3:8][N:7]1[CH2:6][CH2:5][NH:4][CH2:3][C@H:2]1[CH3:1]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 66936371HCID 66936371, compound

Product 1

HCID 66936088(R)-1,2-Dimethyl-piperazine dihydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1,1-Dimethylethyl (3R)-3,4-dimethyl-1-piperazinecarboxylate (2.70 g, 12.6 mmol) in 1N HCl (25 mL) was stirred overnight. Then 4M HCl in 1,4-dioxane (25 mL) was added and the reaction was left to stir overnight. The volatiles were removed in vacuo to provide (2R)-1,2-dimethylpiperazine dihydrochloride as a white solid (2.53 g). LCMS: (M+H)+=115.1.

Workup

  1. waitthe reaction was left
  2. customThe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-43b82bfd29924ea68eb931ab4d446c8d
Source dataset
uspto-grants-2011_02
Patent number
US07893056B2

Reaction notes

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