Methylamine → 4-((Methylamino)methyl)thiazol-2-amine

HRID 1366488Notes

Reaction equation

HRID 1366488 reaction equation
Cl[CH2:2][C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1.[CH3:9][NH2:10]>>[CH3:9][NH:10][CH2:2][C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 732294-Chloromethylthiazol-2-ylamine

Product 1

HCID 189398714-((Methylamino)methyl)thiazol-2-amine

Procedure

4-(Chloromethyl)-1,3-thiazol-2-amine (490 mg, 2.65 mmol) was stirred in 40% aqueous methylamine (25 ml) overnight. The reaction mixture was evaporated. The residue was diluted with 95:5 dichloromethane/methanol (25 ml), was dried over sodium sulfate, was filtered and was evaporated to provide 4-[(methylamino)methyl]-1,3-thiazol-2-amine that was used without purification. LCMS: (M+H)+: 144.0.

Workup

  1. customThe reaction mixture was evaporated
  2. additionThe residue was diluted with 95:5 dichloromethane/methanol (25 ml)
  3. dry with materialwas dried over sodium sulfate
  4. filtrationwas filtered
  5. customwas evaporated

Sources & evidence

ORD record
ord-bc4cbc615a75492997445548ce2f3fe3
Source dataset
uspto-grants-2011_02
Patent number
US07893056B2

Reaction notes

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