Hydrochloric Acid → N,N-dimethyl-5-azaspiro(2.4)heptan-7-amine dihydrochloride

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Reaction Steps

To a solution of racemic N,N-dimethyl-5-(phenylmethyl)-5-azaspiro[2.4]heptan-7-amine (0.8015 g, 3.479 mmol) in MeOH (18 mL) was added 1 N aq. HCl (6.96 mL, 6.96 mmol) and 10% Pd/C (50% water, 160 mg). The mixture was hydrogenated under balloon pressure overnight and then filtered. The solution was concentrated in vacuo to give crude racemic N,N-dimethyl-5-azaspiro[2.4]heptan-7-amine dihydrochloride (0.8060 g, >100% crude yield). LCMS: (M+H)+: 141.1.

Provenance & Evidence