Hydrochloric Acid → 1152111-05-1

HRID 1366515Notes

Reaction equation

HRID 1366515 reaction equation
[CH3:1][N:2]([CH3:17])[CH:3]1[C:7]2([CH2:9][CH2:8]2)[CH2:6][N:5](CC2C=CC=CC=2)[CH2:4]1.[ClH:18]>CO.[Pd]>[ClH:18].[ClH:18].[CH3:1][N:2]([CH3:17])[CH:3]1[C:7]2([CH2:9][CH2:8]2)[CH2:6][NH:5][CH2:4]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66936201HCID 66936201, compound

Product 1

HCID 669363981152111-05-1Yield 108.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of racemic N,N-dimethyl-5-(phenylmethyl)-5-azaspiro[2.4]heptan-7-amine (0.8015 g, 3.479 mmol) in MeOH (18 mL) was added 1 N aq. HCl (6.96 mL, 6.96 mmol) and 10% Pd/C (50% water, 160 mg). The mixture was hydrogenated under balloon pressure overnight and then filtered. The solution was concentrated in vacuo to give crude racemic N,N-dimethyl-5-azaspiro[2.4]heptan-7-amine dihydrochloride (0.8060 g, >100% crude yield). LCMS: (M+H)+: 141.1.

Workup

  1. customwas hydrogenated under balloon pressure overnight
  2. filtrationfiltered
  3. concentrationThe solution was concentrated in vacuo

Sources & evidence

ORD record
ord-64582a033838487fad6e45d315ce610c
Source dataset
uspto-grants-2011_02
Patent number
US07893056B2

Reaction notes

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