HCID 66936424, compound → HCID 66936289, compound

HRID 1366529Notes

Reaction equation

HRID 1366529 reaction equation
[CH3:1][C:2]1([CH3:20])[N:6]([C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:8])[CH2:5][CH:4](C(OC)=O)[C:3]1=[O:19]>CC(O)=O.O>[CH3:1][C:2]1([CH3:20])[C:3](=[O:19])[CH2:4][CH2:5][N:6]1[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8]

Participants

3

Reactant 1

HCID 66936424HCID 66936424, compound

Product 1

HCID 66936289HCID 66936289, compound

Reagents, catalysts & solvents 1

HCID 21899381Acetic acid--water (1/1)Solvent

Procedure

A solution of methyl 5,5-dimethyl-4-oxo-1-(phenylcarbonyl)-3-pyrrolidinecarboxylate (2.5781 g, 9.364 mmol) in 10:1 HOAc-water (50 mL) was heated at 100° C. and stirred for 42 h. The solution was cooled to room temperature and concentrated in vacuo. The residue was dissolved in DCM (200 mL) and washed with sat. aq. NaHCO3. The organic phase was dried over anhydrous MgSO4, filtered, and concentrated in vacuo to afford crude 2,2-dimethyl-1-(phenylcarbonyl)-3-pyrrolidinone as a light yellow oil. LCMS: (M+H)+: 218.1.

Workup

  1. concentrationconcentrated in vacuo
  2. dissolutionThe residue was dissolved in DCM (200 mL)
  3. washwashed with sat. aq. NaHCO3
  4. dry with materialThe organic phase was dried over anhydrous MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-bb4ec966eaad47f3b624e826ba9a18b8
Source dataset
uspto-grants-2011_02
Patent number
US07893056B2

Reaction notes

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