HCID 66936424, compound → HCID 66936289, compound

Participants

Reaction Steps

A solution of methyl 5,5-dimethyl-4-oxo-1-(phenylcarbonyl)-3-pyrrolidinecarboxylate (2.5781 g, 9.364 mmol) in 10:1 HOAc-water (50 mL) was heated at 100° C. and stirred for 42 h. The solution was cooled to room temperature and concentrated in vacuo. The residue was dissolved in DCM (200 mL) and washed with sat. aq. NaHCO3. The organic phase was dried over anhydrous MgSO4, filtered, and concentrated in vacuo to afford crude 2,2-dimethyl-1-(phenylcarbonyl)-3-pyrrolidinone as a light yellow oil. LCMS: (M+H)+: 218.1.

Provenance & Evidence