HRID1366544

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(CNc1nc(Cl)nc(NNC(=O)[C@H](CC2CCCC2)CN(C=O)OCc2ccccc2)c1F)N1CCOCC1

HCID86636982

未命名化合物

PRODUCTS

生成物

结构：CC(C)(CNc1nc(Cl)nc(NNC(=O)[C@H](CC2CCCC2)CN(O)C=O)c1F)N1CCOCC1

HCID58000568

未命名化合物

收率 49%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID9942167

Palladium hydroxide

H2O2Pd

PROCEDURE

实验过程

[(2R)-3-[2-(2-Chloro-5-fluoro-6-{[2-methyl-2-(4-morpholinyl)propyl]amino}-4-pyrimidinyl)hydrazino]-2-(cyclopentylmethyl)-3-oxopropyl][(phenylmethyl)oxy]formamide (0.169 g, 0.28 mmol) and Pd(OH)2 (0.017 g) were treated as described in General Procedure E, Part D, to provide [(2R)-3-[2-(2-chloro-5-fluoro-6-{[2-methyl-2-(4-morpholinyl)propyl]amino}-4-pyrimidinyl)hydrazino]-2-(cyclopentylmethyl)-3-oxopropyl]hydroxyformamide as a white solid (0.070 g, 49%). LCMS: (M+H)+=516.3.