Hydrochloric Acid → HCID 178514348, compound

HRID 1366553Notes

Reaction equation

HRID 1366553 reaction equation
CC(OC([N:8](C(OC(C)(C)C)=O)[N:9]([C:17]1[C:22]([F:23])=[C:21]([NH:24][CH:25]2[CH2:28][CH2:27][CH2:26]2)[N:20]=[C:19]([Cl:29])[N:18]=1)C(OC(C)(C)C)=O)=O)(C)C.Cl>CO.O1CCOCC1>[Cl:29][C:19]1[NH:20][C:21]([NH:24][CH:25]2[CH2:28][CH2:27][CH2:26]2)=[C:22]([F:23])[C:17](=[N:9][NH2:8])[N:18]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86636984HCID 86636984, compound

Product 1

HCID 178514348HCID 178514348, compoundYield 101.2%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of tris(1,1-dimethylethyl)2-[2-chloro-6-(cyclobutylamino)-5-fluoro-4-pyrimidinyl]-1,1,2-hydrazinetricarboxylate (0.495 g, 0.96 mmol) in MeOH (10 mL) was added 4M HCl in 1,4-dioxane (10 mL). The reaction was stirred at room temperature overnight, then the solvent was evaporated, and the residue was treated with a standard K2CO3 aqueous workup to provide 2-chloro-6-(cyclobutylamino)-5-fluoro-4(1H)-pyrimidinone hydrazone as a reddish brown oil (0.225 g). LCMS: (M+H)+=232.0.

Workup

  1. customthe solvent was evaporated
  2. additionthe residue was treated with a standard K2CO3 aqueous workup

Sources & evidence

ORD record
ord-3a243789334e452e8b90c5e53f251330
Source dataset
uspto-grants-2011_02
Patent number
US07893056B2

Reaction notes

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