反应详情

4-Methyl-7-(phenylmethyl)-4,7-diazaspiro[2.5]octane (1.43 g, 6.624 mmol) was dissolved in 10 mL of MeOH, degassed and placed under argon. Pd(OH)2 (140 mg) was added, and the contents were hydrogenated for 4 h under 50 psi. The contents were then filtered to remove the catalyst, 1N HCl (14.57 mL, 14.57 mmol) was added to the filtrate, and the filtrate was concentrated in vacuo to provide pure 4-methyl-4-aza-7-azoniaspiro[2.5]octane, dihydrochloride (0.8 g, 60%). LCMS: (M+H)+: 127.2.

1. customdegassed
2. additionPd(OH)2 (140 mg) was added
3. filtrationThe contents were then filtered
4. additionwas added to the filtrate
5. concentrationthe filtrate was concentrated in vacuo