反应详情

Tris(1,1-dimethylethyl)2-{2-chloro-5-fluoro-6-[(1,3-thiazol-2-ylmethyl)amino]-4-pyrimidinyl}-1,1,2-hydrazinetricarboxylate (0.5826, 1.015 mmol) was dissolved in MeOH (10 mL) and HCl (4M in 1,4-dioxane) (10 mL) at room temperature and stirred overnight. Removal of the solvents in vacuo provided 2-chloro-5-fluoro-6-[(1,3-thiazol-2-ylmethyl)amino]-4(1H)-pyrimidinone hydrazone, presumed dihydrochloride, as a beige solid (0.3507, 100%). LCMS: (M+H)+=274.8.

1. customRemoval of the solvents in vacuo