Hydrochloric Acid → HCID 178514352, compound

HRID 1366602Notes

Reaction equation

HRID 1366602 reaction equation
CC(OC([N:8](C(OC(C)(C)C)=O)[N:9]([C:17]1[C:22]([F:23])=[C:21]([NH:24][CH2:25][C:26]2[S:27][CH:28]=[CH:29][N:30]=2)[N:20]=[C:19]([Cl:31])[N:18]=1)C(OC(C)(C)C)=O)=O)(C)C.Cl>CO>[Cl:31][C:19]1[NH:20][C:21]([NH:24][CH2:25][C:26]2[S:27][CH:28]=[CH:29][N:30]=2)=[C:22]([F:23])[C:17](=[N:9][NH2:8])[N:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86637000Tris(1,1-dimethylethyl) 2-{2-chloro-5-fluoro-6-[(1,3-thiazol-2-ylmethyl)amino]-4-pyrimidinyl}-1,1,2-hydrazinetricarboxylate

Product 1

HCID 178514352HCID 178514352, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Tris(1,1-dimethylethyl)2-{2-chloro-5-fluoro-6-[(1,3-thiazol-2-ylmethyl)amino]-4-pyrimidinyl}-1,1,2-hydrazinetricarboxylate (0.5826, 1.015 mmol) was dissolved in MeOH (10 mL) and HCl (4M in 1,4-dioxane) (10 mL) at room temperature and stirred overnight. Removal of the solvents in vacuo provided 2-chloro-5-fluoro-6-[(1,3-thiazol-2-ylmethyl)amino]-4(1H)-pyrimidinone hydrazone, presumed dihydrochloride, as a beige solid (0.3507, 100%). LCMS: (M+H)+=274.8.

Workup

  1. customRemoval of the solvents in vacuo

Sources & evidence

ORD record
ord-3517c782dcd94a078a61a8693df95eca
Source dataset
uspto-grants-2011_02
Patent number
US07893056B2

Reaction notes

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