反应详情

[(2R)-3-(2-{2-Chloro-5-fluoro-6-[methyl(1,3-thiazol-2-ylmethyl)amino]-4-pyrimidinyl}hydrazino)-2-(cyclopentylmethyl)-3-oxopropyl](tetrahydro-2H-pyran-2-yloxy)formamide was dissolved in acetic acid (8 mL) and water (2 mL). The reaction mixture was left to stir 2 days. The volatiles were evaporated, and the resulting residue was purified by RP-HPLC to provide [(2R)-3-(2-{2-chloro-5-fluoro-6-[methyl(1,3-thiazol-2-ylmethyl)amino]-4-pyrimidinyl}hydrazino)-2-(cyclopentylmethyl)-3-oxopropyl]hydroxyformamide as a beige solid (0.3469 g). LCMS: (M+H)+=486.1.

1. waitThe reaction mixture was left
2. customThe volatiles were evaporated
3. customthe resulting residue was purified by RP-HPLC