HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → L-alpha-Amino-omega-methyl-1-caprolactam
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (S)-tert-butyl 1-methyl-2-oxoazepan-3-ylcarbamate | HCID 60110341 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | L-alpha-Amino-omega-methyl-1-caprolactam | HCID 14003483 | — |
Reaction Steps
To a solution of 1,1-dimethylethyl [(3S)-1-methyl-2-oxohexahydro-1H-azepin-3-yl]carbamate (470 mg, 1.9 mmol) in dioxane (5 mL) was added HCl (4.8 mL, 19 mmol, 4M in dioxane), and the reaction was stirred overnight. Evaporation of the solvent gave a quantitative yield of (3S)-3-amino-1-methylhexahydro-2H-azepin-2-one. LCMS: (M+H)+: 143.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893056B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-5b462b65c8fc4ad9aafea92bd1704200 |
| Source note | uspto-grants-2011_02 |