反应详情

Tris(1,1-dimethylethyl)2-(2,6-dichloro-5-fluoro-4-pyrimidinyl)-1,1,2-hydrazinetricarboxylate (6.22 g, 12.54 mmol) was dissolved in THF (15 mL). To this solution was added triethylamine (2.1 mL, 15.0667 mmol), followed by commercially available (2-furanylmethyl)methylamine (1.394 g, 12.32 mmol) which was dissolved in THF (3 mL). The reaction was left to stir overnight. Then the reaction mixture was diluted with water, and the aqueous layer was extracted with ethyl acetate. The organics were dried (Na2SO4) and concentrated to produce tris(1,1-dimethylethyl)2-{2-chloro-5-fluoro-6-[(2-furanylmethyl)(methyl)amino]-4-pyrimidinyl}-1,1,2-hydrazinetricarboxylate as a beige solid (7.1439 g). LCMS: (M+H)+=572.3.

1. waitThe reaction was left
2. extractionthe aqueous layer was extracted with ethyl acetate
3. dry with materialThe organics were dried (Na2SO4)
4. concentrationconcentrated