反应详情

(2S)-1-(Phenylmethyl)-2-[1-(1-pyrrolidinyl)cyclopropyl]pyrrolidine (1.083 g, 4.00 mmol) was dissolved in a mixture of MeOH (30 mL) and 1N HCl (8.8 mL), degassed and placed under argon. 10% Pd/C (325 mg) was added, and the contents were thoroughly degassed and placed under a hydrogen balloon for 2 h. The contents were then degassed, and the Pd/C was removed by filtration through a fiberglass filter, washing with MeOH. The filtrate was concentrated in vacuo to provide pure 1-{1-[(2S)-2-pyrrolidinyl]cyclopropyl}pyrrolidine hydrochloride (0.978 g, >99%). LCMS: (M+H)+: 181.2.

1. customdegassed
2. addition10% Pd/C (325 mg) was added
3. customthe contents were thoroughly degassed
4. customfor 2 h
5. customThe contents were then degassed
6. customthe Pd/C was removed by filtration through a fiberglass
7. filtrationfilter
8. washwashing with MeOH
9. concentrationThe filtrate was concentrated in vacuo